Histology and Function of the Human Vocal Fold Macula Flava

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Functional histology of the macula flava in the human vocal fold--Part 1: its role in the adult vocal fold.

OBJECTIVE This study aims to clarify the role of the maculae flavae (MFe) in the human adult vocal fold mucosa (VFM). METHODS Our current results concerning MFe in the human adult VFM are summarized. RESULTS MFe were found to be composed of dense masses of vocal fold stellate cells (VFSCs) and extracellular matrices (EM), such as fibrous proteins and glycosaminoglycans, which are essential ...

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Functional histology of the macula flava in the human vocal fold--Part 2: Its role in the growth and development of the vocal fold.

OBJECTIVE This study aims to clarify the role of the maculae flavae (MFe) during growth and development of the human vocal fold mucosa (VFM). METHODS Our current results concerning the MFe in the human newborn, infant, and child VFM are summarized. RESULTS Newborns already had immature MFe at the same sites as adults. They were composed of dense masses of vocal fold stellate cells (VFSCs), ...

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Cell origin in the macula flava of the human newborn vocal fold.

BACKGROUND There is growing evidence to suggest that cells in the maculae flavae are tissue stem cells of the human vocal fold and maculae flavae are a stem cell niche. METHODS Three newborn vocal folds were investigated. Immunoreactivity to antibodies directed to cytokeratin, desmin, glial fibrillary acidic protein, vimentin, cluster of differentiation 34, cluster of differentiation 45, coll...

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Origin of Vocal Fold Stellate Cells in the Human Macula Flava.

OBJECTIVES There is growing evidence that vocal fold stellate cells (VFSCs) in the human maculae flavae are tissue stem cells of the human vocal fold and that the maculae flavae are a stem cell niche. The origin of the cells in the human maculae flavae (CHMF) and the relationship with bone marrow-derived cells were investigated. METHODS Five human adult vocal fold mucosae were investigated. T...

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Morphology of Vocal Fold Mucosa: Histology to Genomics

Voice is created as a consequence of vocal fold vibration. The quality of voice production is dependent upon the uniquely layered ultrastructure of the vocal folds, which is defined by its cellular and extracellular matrices (ECMs). Pathological changes of the vocal fold ECM alter vocal quality secondary to loss of normal vibratory function and alteration of tissue viscosity and thereby create ...

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ژورنال

عنوان ژورنال: Practica Oto-Rhino-Laryngologica

سال: 2003

ISSN: 1884-4545,0032-6313

DOI: 10.5631/jibirin.96.567